Taking GLEEVEC Medication for Ph+ CML
How to Take GLEEVEC
GLEEVEC® is a tablet you take by mouth, not an injection. GLEEVEC is available in 100- and 400-mg scored tablets. The different strengths of GLEEVEC tablets allow your doctor to manage your daily dose in the most effective and convenient way. Your doctor will recommend a starting dose to help you get the best possible results.
GLEEVEC for Ph+ CML
The recommended dose of GLEEVEC is:
- 400 mg/day for adult patients with Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase
- Dose may be increased to 600 mg/day
- 600 mg/day for adult patients in accelerated or blast phase
- Dose may be increased to 800 mg (taken as 400 mg twice daily)
A dose increase may be considered in patients experiencing no severe side effects or severe non–leukemia-related neutropenia or thrombocytopenia in the following circumstances:
- Disease progression (at any time)
- Failure to achieve a satisfactory hematologic response after at least 3 months of treatment
- Failure to achieve a cytogenetic response after 6 to 12 months of treatment
- Loss of a previously achieved hematologic or cytogenetic response
Sometimes disease progression or loss of a previously achieved response results from a gradual resistance to GLEEVEC. Resistance to tyrosine kinase inhibitor (TKI) sometimes occurs if patients do not take their medication as prescribed; however, even patients who take their medication correctly may develop resistance to GLEEVEC. That's why regular scans are so important in monitoring your response to treatment.
If you become resistant or intolerant to GLEEVEC, you have options
There is another treatment option for adult patients with Ph+ CML that is being prescribed for newly diagnosed patients in chronic phase and patients who cannot tolerate or have become resistant to GLEEVEC. Visit www.tasigna.com to read the Important Safety Information and to learn more, and then talk to your doctor to see if TASIGNA is right for you.
Take GLEEVEC exactly as prescribed by your doctor
- Take GLEEVEC with a large glass of water and a full meal
- Do NOT crush GLEEVEC tablets
- GLEEVEC tablets may be dispersed in a glass of water or apple juice (approximately 50 mL or 1.7 oz for a 100-mg tablet, and 200 mL or 6.7 oz for a 400-mg tablet) and stirred with a spoon. The suspension should be administered immediately after complete disintegration of the tablet(s)
- Tell your doctor if you have a history of heart disease or risk factors for heart disease
- Tell your doctor if you have any side effects or questions
Do not take any other medications—including over-the-counter medications such as acetaminophen, vitamins, or herbal supplements—without talking to your doctor or pharmacist first. Taking other medications with GLEEVEC may affect how these drugs work, or affect how GLEEVEC works.
DO NOT TAKE GLEEVEC with grapefruit juice, and ask your doctor about other medications and foods that may affect how GLEEVEC works.
DO NOT CHANGE YOUR DOSE OR STOP TAKING GLEEVEC unless you are told by your doctor. If you miss a dose, take your dose as soon as possible, unless it is almost time for your next dose. In this case, your missed dose should not be taken. DO NOT take a double dose to make up for any missed dose.
DO NOT TAKE GLEEVEC IF...
- You are pregnant or could be pregnant. Harm to the unborn child can occur when administered to pregnant women. Therefore, women should not become pregnant and should be advised of the potential risk to the unborn child if GLEEVEC is used during pregnancy
- You are breast-feeding, because of the potential for serious adverse reactions in nursing infants
- Sexually active females should use highly effective birth control while taking GLEEVEC
Be sure to talk to your doctor and/or nurse about these issues before taking GLEEVEC.
For more important information about taking GLEEVEC, read the Important Safety Information